Dexamethasone (DHAP)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

地塞米松 (DHAP) 是糖皮质激素类类固醇化合物的有效合成成员，也是一种具有抗炎和免疫抑制作用的白细胞介素受体调节剂。

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects(In Vitro):MK-3207 (0.3, 0.6, 1.1, 2.3, 4.5, 9.0 nM; 30 min) potently blocks human α-CGRP-stimulated cAMP responses in human CGRP receptor-expressing HEK293 cells.(In Vivo):MK-3207 (0.3, 0.6, 2.1, 9.1, 21.2, 60.6 μg/kg; i.v.; single) inhibits CIDV in rhesus monkeys with EC50 and Emax values of approximately 0.8 nM and 81%.MK-3207 (10 mg/kg; p.o.; single) shows the CSF/plasma ratio is 2 to 3%.

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DHAP

Endocrinology/Hormones

Annexin A

Annexin A1| Glucocorticoid Receptor| IL receptor| MRP1| iNOS| NR

Inflammation/Immunology

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50-02-2

392.46

C22H29FO5

>98% (HPLC)

Ethanol: 6 mg/mL (15.28 mM); DMSO: 79 mg/mL (201.29 mM)

O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@](C(CO)=O)(O)[C@H](C)C[C@@]4([H])[C@]3([H])CCC2=C1

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

(-20℃)

With Ice Pack

≥ 2 years